Increased glutamic acid decarboxylase expression in the hypothalamic suprachiasmatic nucleus in depression
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چکیده
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Circadian Gene Expression in the Suprachiasmatic Nucleus 901 Circadian Gene Expression in the Suprachiasmatic Nucleus
Regulated expression of a core set of clock genes is the basis of circadian timekeeping in vertebrates, as in other organisms. Clock genes are defined as being necessary to generate normal circadian rhythms, near 24 h oscillations in biological processes. With the enlargement of the brain in vertebrates, control of circadian rhythms became centralized. In lower vertebrates, such as fishes, liza...
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Antibodies directed against the enzyme glutamic acid decarboxylase (GAD) are believed to be the main cause of destruction of pancreatic islet cells in type I (insulin dependent) diabetes mellitus. The enzyme was found both in the brain and pancreatic beta cells. Although similarities in identity of GAD in human and rat brain have been demonstrated, little is known about the interaction betw...
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ژورنال
عنوان ژورنال: Brain Structure and Function
سال: 2017
ISSN: 1863-2653,1863-2661
DOI: 10.1007/s00429-017-1442-y